AUTHOR=Yang Xuyang , Zhang Yang , Zhang Yaguang , Zhang Su , Qiu Lei , Zhuang Zixuan , Wei Mingtian , Deng Xiangbing , Wang Ziqiang , Han Junhong 

TITLE=The Key Role of Exosomes on the Pre-metastatic Niche Formation in Tumors

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.703640

DOI=10.3389/fmolb.2021.703640

ISSN=2296-889X

ABSTRACT=<p>Exosomes or other extracellular vesicles released from cells play an important role in cell-to-cell communication by transferring bio-information (DNA, coding/non-coding RNA, and proteins), which indicates parental cell status to recipient cells in the extracellular environment. Increasingly, evidence shows that tumor-derived exosomes mediate tumor pre-metastatic niche (PMN) remodeling to establish a supportive and receptive niche to promote tumor cell colonization and metastasis. Uptake of genetic information by target cells in the extracellular environment triggers epigenetic changes that contribute to PMN formation. Here, we provide a comprehensive overview of the current understanding of exosomes-mediated reprogramming of cells in PMN formation.</p>