AUTHOR=Li Yanping , Wang Shanshan , Zhang Xiaoyuan , Yang Rui , Wei Xiaonan , Yan Ruirong , Jiang Yaru , Shen Wenzhi 

TITLE=Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.695420

DOI=10.3389/fmolb.2021.695420

ISSN=2296-889X

ABSTRACT=<p>It was proven that PGK1 plays a vital role in the proliferation, migration, and invasion of human breast cancer. However, the correlation of PGK1 mRNA and protein expression with clinicopathologic characteristics and prognostic values according to various kinds of breast cancer patient classifications remains unsufficient. Here, we analyzed data from the Oncomine database, Breast cancer Gene-Expression Miner v4.5, TNMplot, MuTarget, PrognoScan database, and clinical bioinformatics to investigate PGK1 expression distribution and prognostic value in breast cancer patients. Our study revealed that the mRNA and protein expression levels of PGK1 were up-regulated in various clinicopathologic types of breast cancer. Moreover, the expression of PGK1 was correlated with mutations of common tumor suppressor genes TP53 and CDH1. In addition, we found that high mRNA level of PGK1 was significantly associated with poor OS, RFS, and DMFS. Notably, Cox <ext-link ext-link-type="uri" xlink:href="https://cn.bing.com/dict/search?q=regression&amp;FORM=BDVSP6&amp;mkt=zh-cn" xmlns:xlink="http://www.w3.org/1999/xlink">regression</ext-link><ext-link ext-link-type="uri" xlink:href="https://cn.bing.com/dict/search?q=analysis&amp;FORM=BDVSP6&amp;mkt=zh-cn" xmlns:xlink="http://www.w3.org/1999/xlink">analysis</ext-link> showed that PGK1 could be used as an independent prognostic marker. In summary, the aforementioned findings suggested that PGK1 might be not only explored as a potential biomarker, but also combined with TP53/CDH1 for chemotherapy in breast cancer.</p>