AUTHOR=Chen Jiaxuan , Mai Haoming , Chen Haitao , Zhou Bin , Hou Jinlin , Jiang De-Ke 

TITLE=Pan-Cancer Analysis Identified C1ORF112 as a Potential Biomarker for Multiple Tumor Types

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.693651

DOI=10.3389/fmolb.2021.693651

ISSN=2296-889X

ABSTRACT=<p><italic>C1ORF112</italic> is an evolutionarily conserved gene across vertebrates. Over the last decade, studies have suggested that <italic>C1ORF112</italic> may play a role in tumorigenesis. Using The Cancer Genome Atlas datasets, we explored the role of <italic>C1ORF112</italic> across various tumor types in this study. In most tumor types, <italic>C1ORF112</italic> expression was increased in tumor tissues compared to corresponding non-tumor tissues. In patients with certain tumor types, higher <italic>C1ORF112</italic> expression was correlated with shorter overall survival, disease-free survival, and progression-free survival. Further analyses of <italic>C1ORF112</italic> genetic alteration data showed that <italic>C1ORF112</italic> amplification and mutations may have an impact on liver hepatocellular carcinoma and uterine corpus endometrial carcinoma prognosis. In cancers including lower grade glioma and adrenocortical carcinoma, <italic>C1ORF112</italic> expression was linked to cancer-associated fibroblast infiltration. Gene Ontology analysis showed that <italic>C1ORF112</italic> was co-expressed with genes involved in biological processes such as cell cycle and mitotic regulation. The protein interaction network demonstrated that <italic>C1ORF112</italic> physically interacted with <italic>RAD51</italic>, <italic>DMC1</italic>, and <italic>FIGNL1</italic>, which have well characterized functions in DNA repair and cell cycle regulation. This pan-cancer study revealed the prognostic value and oncogenic role of <italic>C1ORF112</italic> across multiple tumor types.</p>