AUTHOR=Dupuy Emile , Collet Jean-François 

TITLE=Fort CnoX: Protecting Bacterial Proteins From Misfolding and Oxidative Damage

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.681932

DOI=10.3389/fmolb.2021.681932

ISSN=2296-889X

ABSTRACT=<p>How proteins fold and are protected from stress-induced aggregation is a long-standing mystery and a crucial question in biology. Here, we present the current knowledge on the chaperedoxin CnoX, a novel type of protein folding factor that combines holdase chaperone activity with a redox protective function. Focusing on <italic>Escherichia coli</italic> CnoX, we explain the essential role played by this protein under HOCl (bleach) stress, discussing how it protects its substrates from both aggregation and irreversible oxidation, which could otherwise interfere with refolding. Finally, we highlight the unique ability of CnoX, apparently conserved during evolution, to cooperate with the GroEL/ES folding machinery.</p>