AUTHOR=Sharifi-Rad Javad , Quispe Cristina , Mukazhanova Zhazira , Knut Ewa , Turgumbayeva Aknur , Kipchakbayeva Aliya , Seitimova Gulnaz , Mahomoodally Mohamad Fawzi , Lobine Devina , Koay Aaron , Wang Jinfan , Sheridan Helen , Leyva-Gómez Gerardo , Prado-Audelo María L. Del , Cortes Hernán , Rescigno Antonio , Zucca Paolo , Sytar Oksana , Imran Muhammad , Rodrigues Célia F. , Cruz-Martins Natália , Ekiert Halina , Kumar Manoj , Abdull Razis Ahmad Faizal , Sunusi Usman , Kamal Ramla Muhammad , Szopa Agnieszka TITLE=Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer JOURNAL=Frontiers in Molecular Biosciences VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.649395 DOI=10.3389/fmolb.2021.649395 ISSN=2296-889X ABSTRACT=

Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.