AUTHOR=Wang Chao , Hu Yiyang , Yang Huan , Wang Sumin , Zhou Bo , Bao Yulu , Huang Yu , Luo Qiang , Yang Chuan , Xie Xia , Yang Shiming 

TITLE=Function of Non-coding RNA in Helicobacter pylori-Infected Gastric Cancer

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.649105

DOI=10.3389/fmolb.2021.649105

ISSN=2296-889X

ABSTRACT=<p>Gastric cancer is a common malignant tumor of the digestive system. Its occurrence and development are the result of a combination of genetic, environmental, and microbial factors. <italic>Helicobacter pylori</italic> infection is a chronic infection that is closely related to the occurrence of gastric tumorigenesis. Non-coding RNA has been demonstrated to play a very important role in the organism, exerting a prominent role in the carcinogenesis, proliferation, apoptosis, invasion, metastasis, and chemoresistance of tumor progression. <italic>H. pylori</italic> infection affects the expression of non-coding RNA at multiple levels such as genetic polymorphisms and signaling pathways, thereby promoting or inhibiting tumor progression or chemoresistance. This paper mainly introduces the relationship between <italic>H. pylori</italic>-infected gastric cancer and non-coding RNA, providing a new perspective for gastric cancer treatment.</p>