AUTHOR=Rajappa Anuva , Banerjee Sucharita , Sharma Vivek , Khandelia Piyush TITLE=Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics JOURNAL=Frontiers in Molecular Biosciences VOLUME=7 YEAR=2020 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2020.577938 DOI=10.3389/fmolb.2020.577938 ISSN=2296-889X ABSTRACT=

Circular RNAs (circRNAs) are rapidly coming to the fore as major regulators of gene expression and cellular functions. They elicit their influence via a plethora of diverse molecular mechanisms. It is not surprising that aberrant circRNA expression is common in cancers and they have been implicated in multiple aspects of cancer pathophysiology such as apoptosis, invasion, migration, and proliferation. We summarize the emerging role of circRNAs as biomarkers and therapeutic targets in cancer.