AUTHOR=Lu Yongqu , Zhou Xin , Liu Zhenzhen , Wang Wendong , Li Fei , Fu Wei TITLE=Characteristic Analysis of Featured Genes Associated With Stemness Indices in Colorectal Cancer JOURNAL=Frontiers in Molecular Biosciences VOLUME=7 YEAR=2020 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2020.563922 DOI=10.3389/fmolb.2020.563922 ISSN=2296-889X ABSTRACT=
Cancer stem cells (CSCs) with self-renewal play an important role in tumor initiation and progression and are associated with drug resistance in cancer therapy. Here, we investigated the characteristics of stem cell-related genes in colorectal cancer (CRC) based on datasets from The Cancer Genome Atlas (TCGA) and Oncomine. We found that the stemness indices were significantly overexpressed in CRC tissues and were associated with patient survival. Weighted gene co-expression network analysis (WGCNA) was performed to determine the modules of stemness and featured genes. Significant modules and 8 genes (