AUTHOR=García-Cárdenas Jennyfer M. , Guerrero Santiago , López-Cortés Andrés , Armendáriz-Castillo Isaac , Guevara-Ramírez Patricia , Pérez-Villa Andy , Yumiceba Verónica , Zambrano Ana Karina , Leone Paola E. , Paz-y-Miño César TITLE=Post-transcriptional Regulation of Colorectal Cancer: A Focus on RNA-Binding Proteins JOURNAL=Frontiers in Molecular Biosciences VOLUME=6 YEAR=2019 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2019.00065 DOI=10.3389/fmolb.2019.00065 ISSN=2296-889X ABSTRACT=

Colorectal cancer (CRC) is a major health problem with an estimated 1. 8 million new cases worldwide. To date, most CRC studies have focused on DNA-related aberrations, leaving post-transcriptional processes under-studied. However, post-transcriptional alterations have been shown to play a significant part in the maintenance of cancer features. RNA binding proteins (RBPs) are uprising as critical regulators of every cancer hallmark, yet little is known regarding the underlying mechanisms and key downstream oncogenic targets. Currently, more than a thousand RBPs have been discovered in humans and only a few have been implicated in the carcinogenic process and even much less in CRC. Identification of cancer-related RBPs is of great interest to better understand CRC biology and potentially unveil new targets for cancer therapy and prognostic biomarkers. In this work, we reviewed all RBPs which have a role in CRC, including their control by microRNAs, xenograft studies and their clinical implications.