AUTHOR=Smith Sarah M. , Baker Michael , Halebian Mary , Smith Corinne J. 

TITLE=Weak Molecular Interactions in Clathrin-Mediated Endocytosis

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=4

YEAR=2017

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2017.00072

DOI=10.3389/fmolb.2017.00072

ISSN=2296-889X

ABSTRACT=<p>Clathrin-mediated endocytosis is a process by which specific molecules are internalized from the cell periphery for delivery to early endosomes. The key stages in this step-wise process, from the starting point of cargo recognition, to the later stage of assembly of the clathrin coat, are dependent on weak interactions between a large network of proteins. This review discusses the structural and functional data that have improved our knowledge and understanding of the main weak molecular interactions implicated in clathrin-mediated endocytosis, with a particular focus on the two key proteins: AP2 and clathrin.</p>