AUTHOR=Bittner Lisa-Marie , Kraus Alexander , Schäkermann Sina , Narberhaus Franz TITLE=The Copper Efflux Regulator CueR Is Subject to ATP-Dependent Proteolysis in Escherichia coli JOURNAL=Frontiers in Molecular Biosciences VOLUME=4 YEAR=2017 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2017.00009 DOI=10.3389/fmolb.2017.00009 ISSN=2296-889X ABSTRACT=
The trace element copper serves as cofactor for many enzymes but is toxic at elevated concentrations. In bacteria, the intracellular copper level is maintained by copper efflux systems including the Cue system controlled by the transcription factor CueR. CueR, a member of the MerR family, forms homodimers, and binds monovalent copper ions with high affinity. It activates transcription of the copper tolerance genes