AUTHOR=Wegrzyn Katarzyna E. , Gross Marta , Uciechowska Urszula , Konieczny Igor 

TITLE=Replisome Assembly at Bacterial Chromosomes and Iteron Plasmids

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=3

YEAR=2016

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2016.00039

DOI=10.3389/fmolb.2016.00039

ISSN=2296-889X

ABSTRACT=<p>The proper initiation and occurrence of DNA synthesis depends on the formation and rearrangements of nucleoprotein complexes within the <italic>origin</italic> of DNA replication. In this review article, we present the current knowledge on the molecular mechanism of replication complex assembly at the <italic>origin</italic> of bacterial chromosome and plasmid replicon containing direct repeats (iterons) within the <italic>origin</italic> sequence. We describe recent findings on chromosomal and plasmid replication initiators, DnaA and Rep proteins, respectively, and their sequence-specific interactions with double- and single-stranded DNA. Also, we discuss the current understanding of the activities of DnaA and Rep proteins required for replisome assembly that is fundamental to the duplication and stability of genetic information in bacterial cells.</p>