AUTHOR=Shahjouei Shima , Ansari Saeed , Pourmotabbed Tayebeh , Zand Ramin TITLE=Potential Roles of Adropin in Central Nervous System: Review of Current Literature JOURNAL=Frontiers in Molecular Biosciences VOLUME=3 YEAR=2016 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2016.00025 DOI=10.3389/fmolb.2016.00025 ISSN=2296-889X ABSTRACT=

Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordination. Adropin is expressed in many tissues and organs including central nervous system (CNS). This peptide plays a crucial role in the development of various CNS disorders such as stroke, schizophrenia, bipolar disorder as well as Alzheimer's, Parkinson's, and Huntington's diseases. In this comprehensive review, the potential roles of adropin in cellular signaling pathways that lead to pathogenesis and/or treatment of CNS disorders will be discussed.