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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1584380
This article is part of the Research TopicLactic Acid Bacteria and their Bioactive Compounds: Key Regulators of Gut Microbiota and Immune FunctionView all 12 articles
Probiotic efficacy and mechanism of a pigeon derived Ligilactobacillus salivarius strain in promoting growth and intestinal development of pigeons
Provisionally accepted
Puze Zhao1Yumei Li1Yuwei Yang1Qingxing Xiao1Ziyi Zhang1
Xiaoqing Hong1Hongyu Ni1Zhuxuan Xia1Kun Zhan1Sibao Yang2*
Yonghong Zhang1*- 1Jilin University, Changchun, China
- 2China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China
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To evaluate and elucidate the probiotic efficacy and mechanisms during homologous lactic acid bacteria (LAB) transplant to host-pigeons, this study isolated and identified Ligilactobacillus salivarius S10 with good probiotic properties from the intestinal contents of 28-day-old Mimas pigeons. Then, total of 360 1-day-old pigeons were randomly divided into four groups and gavaged 0.4 mL L. salivarius S10 with concentration of 0, 10 8 , 10 9 , and 10 10 CFU/mL, designated as the control group (CG), the low concentration group (LG), the medium concentration group (MG), and the high concentration group (HG), respectively. The findings revealed that an optimal concentration of 10 9 CFU/mL L. salivarius S10 enhanced the growth performance and intestinal development of young pigeons. 16S rRNA gene sequencing analysis demonstrated a increase in the abundance of Lactobacillus, Pantoea_A and Enterococcus_H and a reduction in the abundance of Clostridium_T in the pigeon ileum (p < 0.05) under selected concentration treatment. Transcriptomic profiling of the ileum revealed 1828 differentially expressed genes (DEGs) between CG and MG. Notably, DEGs involved in the MAPK signaling pathway, such as RAF1, PDGFRB, and ELK4, exhibited significant correlations with the differential ileal bacteria, suggesting that modulation of the intestinal flora can influence the expression of genes related to cell proliferation and differentiation in the ileum. These findings hold potential significance in promoting the growth and development of pigeons, thereby contributing to advancements in pigeon agriculture.
Keywords: pigeon, Ligilactobacillus salivarius, Production performance, intestinal flora, Intestinal transcriptomics
Received: 27 Feb 2025; Accepted: 21 Apr 2025.
Copyright: © 2025 Zhao, Li, Yang, Xiao, Zhang, Hong, Ni, Xia, Zhan, Yang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Sibao Yang, China-Japan Union Hospital, Jilin University, Changchun, 130033, Jilin Province, China
Yonghong Zhang, Jilin University, Changchun, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.