REVIEW article
Front. Microbiol.
Sec. Microbial Symbioses
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1580661
Intestinal immunoglobulins under microbial dysbiosis: Implications in opioid-induced microbial dysbiosis
Provisionally accepted
- 1 Department of Microbiology and Immunology, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States
- 2 Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, United States
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Intestinal immunoglobulins (Igs) maintain homeostasis between the microbiome and host. IgA facilitates microbial balance through a variety of increasingly well-described mechanisms. However, IgM and IgG have less defined intestinal functions but have the potential to activate clearance mechanisms such as the complement system and receptor-mediated bacterial killing. Very little is known regarding the role of Igs under microbial dysbiosis. In this review, we explore how Igs sculpt the intestinal microbiome and respond to microbial dysbiosis. We discuss how IgM, IgA, IgG, and complement individually maintain harmony with the microbiome and consider how these mechanisms could work in synergy. Finally, we explore using an opioidinduced microbial dysbiosis as a model to elucidate immediate changes in Ig-bacterial interactions.Deleted: Here, we explore the individual roles of intestinal Igs and complement, and postulate on the synergistic implications of Igs and complement in maintaining microbial homeostasis.…
Keywords: IgA, IgM, IgG, complement, Opioids, intestinal immunity, microbiome
Received: 20 Feb 2025; Accepted: 25 Mar 2025.
Copyright: © 2025 Vitari and Roy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Sabita Roy, Department of Microbiology and Immunology, Leonard M. Miller School of Medicine, University of Miami, Miami, 33136, Florida, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
