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REVIEW article

Front. Microbiol.

Sec. Virology

Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1565350

Orthoflavivirus Infection and the mTOR Signaling Pathway

Provisionally accepted
  • 1 Naval Medical University, Shanghai, Shanghai, China
  • 2 Tongji University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Each year, mosquito-borne orthoflaviviruses, including Zika virus, dengue virus, and the Japanese encephalitis virus, threaten the health of more than 400 million people worldwide. To date, knowledge about the pathogenic mechanisms underlying orthoflavivirus infection and the interactions of these viruses with host cells is limited. Mammalian target of rapamycin (mTOR) is pivotal for cell growth and metabolism. The downstream targets of mTOR regulate protein translation and cell autophagy to affect orthoflavivirus replication, and its upstream protein AKT performs similar functions. In this work, the mechanism underlying the relationship between the mTOR signaling pathway and orthoflavivirus infection was reviewed from three perspectives: orthoflavivirus structure and life cycle, mTOR structure and signaling pathway, and regulation of the mTOR signaling pathway during orthoflavivirus infection.

    Keywords: Orthoflavivirus, Dengue Virus, Zika virus, mTOR signaling pathway, viral replication

    Received: 23 Jan 2025; Accepted: 26 Mar 2025.

    Copyright: © 2025 Liu, Zhang, Ba, Luan and Qi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bin Liu, Naval Medical University, Shanghai, 200433, Shanghai, China
    Zhongtian Qi, Naval Medical University, Shanghai, 200433, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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