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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1560368
The Role of Gut Microbiota in Predicting the Weight Loss Following Laparoscopic Sleeve Gastrectomy
Provisionally accepted- 1 Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
- 2 Department of Nursing, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
- 3 Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Graduate School, Zhejiang University, Hangzhou, China
Background: Laparoscopic sleeve gastrectomy (LSG) has emerged as a highly effective intervention in the management of obesity. While there has been a recent surge in research exploring the relationship between obesity and gut microbiota, the association between gut microbiota and LSG remains relatively underexplored. This study aimed to investigate the relationship between gut microbiota and both early and later effects of LSG.In this retrospective study, clinical characteristics and preoperative fecal samples were collected from fifty-two individuals who underwent LSG. Using 16S rRNA gene sequencing, we compared the community composition, alpha diversity, and beta diversity of gut microbiota between patients who experienced efficient weight loss and those who did not. Additionally, comprehensive and correlation analyses were performed to identify potential associations between specific microbial taxa and LSG outcomes.The abundances of gut microbiota in patients who experienced efficient weight loss and those who experienced general weight loss were comparable. However, the influence of gut microbiota on the efficacy of weight loss is dynamic. Specifically, the Fusobacteriota phylum significantly contributed to the early curative effects of LSG, while Actinobacteriota had a greater impact on the late curative effects.Additionally, Proteobacteria were found to mediate long-term efficacy through complex mechanisms.Conclusions: This study analyzed the preoperative gut microbiota signature to predict the efficacy of LSG, potentially offering valuable insights for clinical applications. Preoperative assessment of gut microbiota profiles could assist patients in their decision-making processes, particularly regarding the potential outcomes of LSG and the long-term impact of the procedure on their health.
Keywords: Laparoscopic sleeve gastrectomy, Gut Microbiota, Weight Loss, Efficiency, Dynamically
Received: 20 Jan 2025; Accepted: 10 Feb 2025.
Copyright: © 2025 Chen, Shen, Shen, Zhu, Yu, Tong and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hong Yu, Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Yifan Tong, Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Graduate School, Zhejiang University, Hangzhou, China
Weihua Yu, Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
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