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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Microbial Physiology and Metabolism
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1554102
The LysR-type transcriptional regulator STY2660 is involved in outer membrane protein synthesis, bile resistance and motility in Salmonella enterica serovar Typhi
Provisionally accepted
Yitzel Gama-Martínez 
Victor Manuel Hernández-López 
Sergio Encarnacion-Guevara Ángel Gabriel Martínez-Batallar 
Ismael Hernandez-Lucas *- UNAM Campus Morelos, National Autonomous University of Mexico, Cuernavaca, Mexico
Salmonella enterica serovar Typhi, the etiological agent of Typhoid fever in humans, contains 44 LysR-type transcriptional regulators (LTTRs), most of which are annotated as hypothetical proteins whose roles are not yet described. In this work we demonstrated by mutants, growth evaluation in bile salts, transcriptional fusions, EMSAs, outer membrane protein profiles and motility assays, that the S. Typhi LTTR STY2660 is involved in two regulatory networks: FNR-STY2660-OmpR-OmpC for porin synthesis and bile resistance and FNR-STY2660-OmpR-FliD for motility. Thus, the LTTR STY2660 is able to establish genetic communication with master regulatory proteins to promote and efficiently respond to adverse conditions present in the host.
Keywords: S. Typhi, LysR regulator, bile resistance, motility, Outer membrane protein (OMP)
Received: 31 Dec 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Gama-Martínez, Hernández-López, Encarnacion-Guevara, Martínez-Batallar and Hernandez-Lucas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ismael Hernandez-Lucas, UNAM Campus Morelos, National Autonomous University of Mexico, Cuernavaca, Mexico
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