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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1553943
A Retrospective Study of the Antimicrobial Susceptibility Patterns of Klebsiella pneumoniae Isolated from Urine Samples Over a Decade in South India
Provisionally accepted
Yogeesh D Maheshwarappa
Supreeta Shettar
Kalyani G
Sumana Mahadevaiah*
Tejashree A
Rashmi P MahaleSowmya G ShivappaMorubagal RaghavendraRanjitha ShankaregowdaVidyavathi B ChitaragiDeppashree RSujatha S RNeetha S MurthyBadveti Satya SaiPreethika RaviVasimalli Vinay Kumar- Department of Microbiology, JSS Medical College and Hospital, JSS AHER, Mysuru, India
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Introduction: Urinary tract infections (UTIs) are common bacterial infections with significant health implications. This study aimed to assess the antimicrobial susceptibility (AST) patterns of Klebsiella pneumoniae (KPN) isolated from urine samples over a decade (2014 to 2023). Methods: The study analyzed Klebsiella pneumoniae isolates AST pattern from urine samples at a tertiary care hospital in Mysuru (Karnataka), South India using the VITEK-2 (bioMérieux, France) database. Results: Of 73,283 urine samples, 21,362 (29.15%) showed significant bacterial growth. The most frequently isolated organism was Escherichia coli (n=9,211, 43.11%), followed by Pseudomonas aeruginosa (n=1,108, 5.18%) and K. pneumoniae (n = 920, 4.30%). Of the 920 K. pneumoniae isolates, 385(41.84%) were carbapenem-resistant (CRKP). Isolation rates were higher in males (n = 229, 59.48%) than females (n = 156, 40.52%), with a statistically significant p-value (<0.0001). Carbapenem resistance rose from 3.70% in 2014 to 66.13% in 2021, then declined to 38.55% in 2023. Resistance to fluoroquinolones, aminoglycosides, and cephalosporins increased, with cephalosporin resistance exceeding 85% by 2023. These trends reflect growing drug resistance among K. pneumoniae.The study reveals a significant rise in K. pneumoniae resistance, particularly to carbapenems and fluoroquinolones. Effective treatment requires antibiotic stewardship, strict infection control, and ongoing surveillance to maintain therapeutic options.
Keywords: Klebsiella pneumoniae, Carbapenem resistant Klebsiella pneumoniae, Urinary tract infection (UTI), antimicrobial susceptiblity pattrens, Multidrug resistant organism (MDRO), Antimicrobial resitance, Antibiotic policies
Received: 07 Jan 2025; Accepted: 18 Apr 2025.
Copyright: © 2025 Maheshwarappa, Shettar, G, Mahadevaiah, A, Mahale, Shivappa, Raghavendra, Shankaregowda, Chitaragi, R, R, Murthy, Sai, Ravi and Kumar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sumana Mahadevaiah, Department of Microbiology, JSS Medical College and Hospital, JSS AHER, Mysuru, India
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.