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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1551693
Studies on the changes in rectal permeability and intestinal microbiota with developmental age in young rats
Provisionally accepted- 1 Discipline of Chinese and Western Integrative Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
- 2 Yudu County Hospital of Traditional Chinese Medicine, ganzhou, China
- 3 Jiangxi University of Traditional Chinese Medicine, Nanchang, China
Our study aimed to investigate the differences in rectal permeability and gut microbiota among young rats of different age groups, as well as the differences in rectal permeability among rat of various ages and the underlying causes. This research focused on the physiological characteristics of the rectum in early developmental stages, highlighting the correlation between rectal permeability and changes in gut microbiota. Additionally, we proposed new recommendations regarding the dosage of rectal administration in pediatric populations. While extensive research has been conducted on microorganisms in the digestive systems of vertebrates, particularly in the small intestine, there is less emphasis on the rectum, especially in children.Our article specifically addresses the relationship between the rectum of rats at specific ages and the microorganisms present within it, aligning closely with the focus of this chapter.
Keywords: early development, Rectum, Permeability, microbiota, Tight Junction Proteins
Received: 26 Dec 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Luo, Luo, Xia, Liu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
qian Liu, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
guosong Zhang, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
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