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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1550742
This article is part of the Research TopicBioinformatics approaches to investigate antimicrobial resistance (AMR) in human, animal and environmentView all 12 articles
Molecular epidemiology of New Delhi metallo-beta-Lactamase producing Escherichia coli from chicken at retail market in Shandong, China
Provisionally accepted- 1Liaocheng University, Liaocheng, China
- 2Yulin Normal University, Yulin, Shaanxi, China
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The global spread of carbapenem-resistant Escherichia coli is a major public health concern. An investigation of their presence in the human and food chain products would facilitate the elucidation of the route of their food-borne transmission. Thus, the aim of this study was to investigate the prevalence of NDM-positive E. coli isolates in chicken at retail markets in Shandong, China. A total of 60 NDM-positive isolates were recovered from 531 E. coli isolates obtained from chickens at the retail market in Shandong. All of these isolates were multidrug-resistant (MDR), with a majority exhibiting resistance to meropenem, ampicillin, ceftazidime, cefotaxime, florfenicol, sulfamethoxazole/trimethoprim, and tetracycline. Whole genome sequencing (WGS) analysis indicated that these isolates were belonged to 18 distinct sequence types (STs), with the most prevalent STs being ST515 (17/60) and ST69 (11/60). Additionally, WGS analysis revealed that clonal spread of NDM-positive ST69 and ST515 E. coli isolates at markets in different cities in Shandong. Phylogenomic analysis showed that NDM-positive E. coli isolates from chickens were closely related to those of human origin. This study provides a new insight into the spread of NDMpositive E. coli isolates from retail chicken, and offers essential data for public health management.
Keywords: carbapenemase, E. coli, BlaNDM, mlst, ARGS
Received: 24 Dec 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Wang, Ma, Bai, Xu, He, Qi and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Min-ge Wang, Liaocheng University, Liaocheng, China
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