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MINI REVIEW article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1549895
This article is part of the Research TopicBreastfeeding's Role in Shaping Infant Gut Microbiota for Long-Term HealthView all 7 articles
Gut Microbiota Modulation: A Key Determinant of Atopic Dermatitis Susceptibility in Children
Provisionally accepted- 1West China Hospital, Sichuan University, Chengdu, China
- 2Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, 610041, China, Chengdu, Sichuan Province, China
- 3Chengdu Shude High School, Chengdu, Sichuan Province, China
- 4Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa
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Atopic dermatitis is a chronic inflammatory skin condition with a higher incidence rate among children. In recent years, the role of the gut microbiota in the pathogenesis of atopic dermatitis has garnered increasing attention. This review systematically delineates the research advancements in the structural characteristics of the gut microbiota in children with atopic dermatitis and its influencing factors. Studies have revealed significant differences in the gut microbiota structure between children with atopic dermatitis and healthy controls, characterized by a reduction in microbial diversity, a decrease in beneficial bacteria, and an increase in harmful bacteria. Dietary patterns, environmental factors, birth patterns, antibiotic use, and gestational diabetes mellitus are factors could impact the gut microbiota hence influencing the susceptibility of children to atopic dermatitis. Moreover, this review explores the interplay between the gut microbiota and the immune system in atopic dermatitis, with the potential to inform more effective probiotic treatment strategies for children with atopic dermatitis.
Keywords: atopic dermatitis, Children, gut microbiome, Structural feature, influencing factor
Received: 22 Dec 2024; Accepted: 14 Apr 2025.
Copyright: © 2025 Tang, Li, Xu, Zhou, Hamblin and Wen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Michael R Hamblin, Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa
Xiang Wen, West China Hospital, Sichuan University, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.