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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Food Microbiology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1549853
This article is part of the Research Topic Probiotics for Global Health: Advances, Applications and Challenges View all 21 articles
Dietary Purslane Modulates Gut Microbiota and Fecal Metabolites in Aging Rats
Provisionally accepted
Qiang Fu 1*
Jingwen Deng 1 Xia Wang 2 Can Yan 1 Zicheng Huang 3 Hui Luo 4 Caihua Dai 4
Yushan Huang 5*
Xiaoliu Huang 1*- 1 The Affiliated Hospital of Jinggangshan University, Ji'an, Jiangxi Province, China
- 2 Ji'an Central People's Hospital, Ji'an, Jiangxi Province, China
- 3 Xinjiang Agricultural University, Ürümqi, Xinjiang Uyghur Region, China
- 4 College of Medicine, Jinggangshan University, Ji'an, Jiangxi Province, China
- 5 First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
Portulaca oleracea. L (purslane) is a highly nutritious and edible wild vegetable that has many beneficial effects on human health. However, its effects on the structure of gut microbiota and fecal metabolites in aging individuals are still unclear. This study aims to elucidate its potential mechanisms in aging related gut health. Naturally aged rats (18 months) were fed either a maintenance chow or a mixture with 3.5% purslane for 15 weeks. Hematoxylin-eosin staining, gas chromatography-mass spectrometry, and 16S rDNA high-throughput sequencing were used to explore purslane's effects on these rats' intestinal health. The results showed that the fecal concentrations of acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, and total short-chain fatty acids (SCFAs) were significantly increased in the aging rats fed the purslane supplement. Further analysis showed that purslane significantly reduced the relative abundance levels of Firmicutes and Fusobacteria, as well as the ratio of Firmicutes to Bacteroidetes. To elaborate, 109 differential metabolites were annotated via KEGG 删除了: Regula
Keywords: Gut Microbiota, Metabolites, Intestinal health, Aging rats, Purslane
Received: 22 Dec 2024; Accepted: 27 Feb 2025.
Copyright: © 2025 Fu, Deng, Wang, Yan, Huang, Luo, Dai, Huang and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qiang Fu, The Affiliated Hospital of Jinggangshan University, Ji'an, Jiangxi Province, China
Yushan Huang, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
Xiaoliu Huang, The Affiliated Hospital of Jinggangshan University, Ji'an, Jiangxi Province, China
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