REVIEW article
Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1549572
The Role of Metformin in Tuberculosis Control Among TB and Diabetes Mellitus Comorbid Individuals
Provisionally accepted
- Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
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Tuberculosis (TB) is a major global health concern, and its control is particularly hindered in patients with comorbidities such as type 2 diabetes mellitus (TBDM). Metformin, a commonly prescribed antidiabetic medication, has gained attention because of its potential role in improving TB treatment outcomes in patients with TBDM. This review aims to assess the role of metformin in TB case management among TBDM comorbid individuals. By reviewing the available literature, we aimed to explore the potential benefits, complications, mechanisms, and considerations surrounding metformin use as an adjunctive therapy for TB treatment. The findings of this review will shed light on current understanding and highlight areas for further investigation.
Keywords: Mycobacterium tuberculosis, Metformin, Host-directed therapeutics, diabetes, TB-Diabetes patients, immunomodulatory
Received: 21 Dec 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 Tetteh, Danso, Osei-Wusu, Yeboah-Manu and Asare. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prince Asare, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
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