ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1546166
This article is part of the Research Topic Women in Infectious Agents and Disease: 2024 View all 10 articles
Epidemiologic evaluation of human papillomavirus type competition in unvaccinated women from Xiamen, China
Provisionally accepted
Yu Chen 1,2 Qing Li 3 Liya Du 4 Zhuowen Du 2 Yixi Zhou 1,5 Yanru Huang 1,5 Jian Zhang 1,5 Wenbo Wang 1,5 Lutan Zhang 1,5 Jieqiong Xie 1,5 Chao Xu 6 Yunsheng Ge 1,5* Xingmei Yao 1,5* Yulin Zhou 2,5,7*- 1 Department of Central Laboratory, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China, xiamen, China
- 2 United Diagnostic and Research Center for Clinical Genetics, Women and Children’s Hospital, School of Medicine and School of Public Health, Xiamen University, Xiamen, Fujian, China
- 3 Department of Women health care, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China, Xiamen, China
- 4 Department of Quality control, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China, Xiamen, China
- 5 The Key Clinical Specialty of Fujian Province, Department of Clinical Laboratory at Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China, Xiamen, Fujian Province, China
- 6 Department of Information center, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China, Xiamen, China
- 7 Department of Central Laboratory, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province, China
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Background: Human papillomavirus (HPV) vaccination is expected to reduce the burden of cervical cancer and other HPV-related diseases. However, if competition exists among HPV types, type replacement may occur following the reduction of vaccine-targeted types. Here, we conducted the study to explore natural HPV type competition in unvaccinated women.Methods: HPV DNA test results from cervical samples collected between January 2013 and July 2023 at Xiamen University's Women and Children's Hospital were analyzed. In cross-sectional study, first-visit HPV genotyping results were used, and logistic regression model was constructed to evaluate interactions between vaccinetargeted and other HPV types. In cohort of women with multiple visits, the risk of acquiring other HPV types was compared between women infected with vaccine-3 targeted types and those HPV-negative using Cox proportional hazards model.Results: Among 159,049 women, 19.8% tested HPV-positive, with 5.1% having multiple types. Significant negative associations were observed between HPV-6 and HPV-72 (OR: <0.01; 95%CI: <0.01-0.03), HPV-18 and HPV-72 (OR: <0.01; 95%CI: <0.01-0.02), HPV-31 and HPV-83 (OR: <0.01; 95%CI: <0.01-0.55), HPV-33 and HPV-26 (OR: <0.01; 95%CI: <0.01-0.81), HPV-45 and HPV-55 (OR: <0.01; 95%CI: <0.01-<0.01), HPV-56 and HPV-26 (OR: <0.01; 95%CI: <0.01-0.09), as well as HPV-59 and HPV-69 (OR: <0.01; 95%CI: <0.01-0.68), suggesting potential type competition. However, no type competition pair was found in the cohort study.Conversely, women with vaccine-targeted types had a higher risk of acquiring other types (HR >1.0).
Keywords: Human papillomavirus (HPV), Infection, Type competition, cervical cancer, HPV vaccine
Received: 16 Dec 2024; Accepted: 18 Mar 2025.
Copyright: © 2025 Chen, Li, Du, Du, Zhou, Huang, Zhang, Wang, Zhang, Xie, Xu, Ge, Yao and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yunsheng Ge, Department of Central Laboratory, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China, xiamen, China
Xingmei Yao, Department of Central Laboratory, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China, xiamen, China
Yulin Zhou, United Diagnostic and Research Center for Clinical Genetics, Women and Children’s Hospital, School of Medicine and School of Public Health, Xiamen University, Xiamen, Fujian, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
