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REVIEW article
Front. Microbiol.
Sec. Virology
Volume 16 - 2025 |
doi: 10.3389/fmicb.2025.1543676
Post-Translational Modifications as a Key Mechanism for Herpes Simplex Virus Type I Evasion of Host Innate Immunity
Provisionally accepted
YONGXING ZHANG 1
Junlei Xie 1
Ying Feng 1*
Abdul Qadeer 1 Shanni Li 1* Xu Deng 1*
Lipeng Zhu 1 Bo Kong 2*
Zanxian Xia 1,3*- 1 Central South University, Changsha, China
- 2 China Tobacco Hunan Industrial, Changsha, China
- 3 Key Laboratory of Hunan Province for Research on Animal Models of Human Major Diseases, School of Life Science, Central South University, Changsha, Anhui Province, China
Herpes simplex virus type 1 (HSV-1) is a DNA virus that infects humans and establishes long-term latency within the host. Throughout its prolonged interaction with the host, HSV-1 evades the innate immune system by encoding its own proteins. Post-translational modifications (PTMs) of these proteins play crucial roles in their function, activity, and interactions with other factors by modifying specific amino acids, thereby enabling a diverse range of protein functions. This review explores the mechanisms and roles of PTMs in HSV-1-encoded proteins, such as phosphorylation, ubiquitination, deamidation, and SUMOylation, during HSV-1 infection and latency. These modifications are essential for suppressing host innate immunity, facilitating viral replication, and elucidating the crosstalk among various post-translational modifications.
Keywords: herpes simplex virus type I, innate immunity, Immune Evasion, post-translational modifications, Ubiquitination 1
Received: 11 Dec 2024; Accepted: 24 Jan 2025.
Copyright: © 2025 ZHANG, Xie, Feng, Qadeer, Li, Deng, Zhu, Kong and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ying Feng, Central South University, Changsha, China
Shanni Li, Central South University, Changsha, China
Xu Deng, Central South University, Changsha, China
Bo Kong, China Tobacco Hunan Industrial, Changsha, China
Zanxian Xia, Central South University, Changsha, China
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