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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Food Microbiology
Volume 16 - 2025 |
doi: 10.3389/fmicb.2025.1542522
This article is part of the Research Topic The Interaction Between Food Ingredients and Gut Microbiome on Health and Disease View all 7 articles
Pasteurized Akkermansia muciniphila Timepie001 ameliorates DSS-induced ulcerative colitis in mice by alleviating intestinal injury and modulating gut microbiota
Provisionally accepted
Huan Han 1,2
Hui Xiong 1 Zengli Liu 1 Xunzhi Liu 3
Hailin Wang 4 Jiaxiang Kou 1 Dewei Yi 1 Ying Shi 3
Hao Wu 1,2*
Jianjun Qiao 1,2*- 1 Zhe Jiang institute of Tianjin university, Shaoxing, China
- 2 School of Chemical Engineering and Technology, Tianjin University, Tianjin, Tianjin, China
- 3 Shanghai Fuyang Biotechnology co., ltd, Shanghai, China, Shanghai, China
- 4 College of Food and Bioengineering, Fujian Polytechnic Normal University, Fuqing, Fujian, China, Fujian, China
Akkermansia muciniphila (A. muciniphila), known as a next-generation probiotic, has been widely recognized for its beneficial effects in various metabolic diseases. While there is not much research whether live or pasteurized A. muciniphila has different effects on intestinal health. In the present study, a strain of A. muciniphila was isolated from healthy individuals, with the live and pasteurized A. muciniphila named Timepie001 and Timepie001+, respectively. They were administered to dextran sulfate sodium-induced ulcerative colitis mice to investigate their influences on the host intestinal health. The results showed that prophylactic supplementation with live and pasteurized A. muciniphila alleviates ulcerative colitis symptoms by retarding weight loss, preserving intestinal tissue structure, modulating inflammatory cytokines (TNF-α, IL-1β), and enhance the colonic mucosal barrier by upregulating the expression of tight junction protein Claudin-1. Interestingly, pasteurized A. muciniphila has a better effect compared with live A. muciniphila. Moreover, pasteurized A. muciniphila can regulates the gut microbiome to maintain intestinal homeostasis. This provides theoretical support for the widespread application of postbiotics in the food industry.
Keywords: muciniphila, Timepie001, ulcerative colitis, Gut Microbiota, Intestinal regulation
Received: 10 Dec 2024; Accepted: 03 Feb 2025.
Copyright: © 2025 Han, Xiong, Liu, Liu, Wang, Kou, Yi, Shi, Wu and Qiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hao Wu, Zhe Jiang institute of Tianjin university, Shaoxing, China
Jianjun Qiao, Zhe Jiang institute of Tianjin university, Shaoxing, China
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