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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 16 - 2025 |
doi: 10.3389/fmicb.2025.1540843
This article is part of the Research Topic Bacterial Pathogens and Virulence Factor Genes: Diversity and Evolution View all 12 articles
Genomic identification of a pair of multidrug-resistant but nonpathogenic Salmonella enterica serovar Goldcoast isolates in southeast China
Provisionally accepted- 1 Jiashan County Center for Disease Control and Prevention, Jiaxing, China
- 2 Jiaxing Center for Disease Control and Prevention, Zhejiang, China
- 3 First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Salmonella is an important foodborne pathogen that can induce severe diseases such as gastrointestinal disease and typhoid fever. Accumulating evidence revealed that Salmonella's resistance to antibiotics also seriously affects human health. Pathogenic Salmonella enterica serovar Goldcoast (S. Goldcoast) was first detected in 2010 in China and was predicted to have an increasing tendency. Herein, two nonpathogenic isolates with multidrug resistance, JS33 and JS34, harbored 42 antibiotic-resistant genes (ARGs) in contig1 and 13 ARGs in contig2, were isolated from a healthy donor living in southeast China and identified as S. Goldcoast (6,8:r:l,w). Interestingly, JS33 and JS34 showed identical responses to more than 20 antimicrobial agents and were resistant to ampicillin, selectrin, chloramphenicol, tetracycline, and streptomycin. However, JS33 differed from JS34 in hydrogen sulfide (H2S) generation. The genomic sequencing identified a deletion in thiosulfate reductase (K08352) in JS34. H2S is an essential physiological regulator linked to inflammation and cancer. Therefore, genomic identification of JS33 and JS34 provided us with a better understanding of drug resistance and could be used as model strains to study the effects of microbial H2S production on the host. Since JS33 and JS34 did not induce gastrointestinal infection or other clinical symptoms as previously reported, the appearance of non-pathogenic S. Goldcoast in southeast China warned us to prepare for the prevalence of antimicrobial-resistant S. Goldcoast in China.
Keywords: Salmonella enterica serovar Goldcoast, multidrug resistance, β-lactamase, H2S generation, Thiosulfate reductase
Received: 17 Dec 2024; Accepted: 24 Jan 2025.
Copyright: © 2025 Yuan, Li, Shen, Li, He and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bin Zhou, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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