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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1535490
This article is part of the Research Topic Hot Topics 2023: Systematic approaches to Respiratory Diseases: Pathology and Therapeutics View all 7 articles

Diagnostic value of the combined test of leukocytes in urine and TB-DOT and T-SPOT.TB in blood for urinary tuberculosis

Provisionally accepted
Yanyan Li Yanyan Li Yachun Wang Yachun Wang Lukuan Wei Lukuan Wei Wei Wang Wei Wang *
  • zhengzhou university, Henan Provincial Chest Hospital, Zhengzhou, China

The final, formatted version of the article will be published soon.

    Background: This study aims to evaluate the clinical utility of routine urinary tests and renal function assessments, as well as the Tuberculosis antibody test (TB-DOT) and T-2 cell spot tests for TB infection (T-SPOT.TB), either individually or in combination, for diagnosing urinary tuberculosis (UTB). Methods: We conducted a retrospective analysis of urinary routine tests, renal function tests, TB-DOT, and T-SPOT.TB-administered alone or in combination-in 95 patients suspected of having UTB from January 2020 to December 2022 at our institution. Results: Significant differences were observed in the levels or positivity of white blood cells (WBC), red blood cells (RBC), creatinine (Crea), TB-DOT, and T-SPOT.TB between the UTB group and the non-UTB group (P<0.05). Among the individual tests, T-SPOT.TB exhibited the highest specificity and positive predictive value (PPV), while WBC demonstrated the highest area under the curve (AUC). Both TB-DOT and RBC showed relatively good sensitivity. Additionally, WBC levels correlated with both TB-DOT and T-SPOT.TB results. The combination of WBC, TB-DOT, and T-SPOT.TB provided the best sensitivity, negative predictive value (NPV), and AUC when evaluated in parallel with the other tests. Conclusion: For the early identification of UTB, the sensitivity of T-SPOT.TB and TB-DOT tests is superior to that of routine urinary and renal function tests. The parallel combination of WBC, TB-DOT, and T-SPOT.TB offers enhanced diagnostic efficacy for UTB, facilitating rapid clinical diagnosis.

    Keywords: Urinary tuberculosis, Non-urinary tuberculosis, White blood cell, Tuberculosis antibody test, T-cell spot tests for tuberculosis infection, Creatinine

    Received: 27 Nov 2024; Accepted: 10 Jan 2025.

    Copyright: © 2025 Li, Wang, Wei and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wei Wang, zhengzhou university, Henan Provincial Chest Hospital, Zhengzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.