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REVIEW article
Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1531543
This article is part of the Research Topic Leveraging Real-Time Genomic Surveillance to Combat Infectious Diseases and Antimicrobial Resistance View all articles
Genomics Insights of Candidiasis: Mechanisms of Pathogenicity and Drug Resistance
Provisionally accepted
Xin Huang 1,2
Qin Dong 1* Qi Zhou 1* Shitao Fang 1* Yiheng Xu 1* Hongjie Long 1* Jingyi Chen 1* Xiao Li 1* Huaguang Qin 1* Dan Mu 1*
Xunchao Cai 3,4*- 1 Anqing Normal University, Anqing, China
- 2 Nanjing University, Nanjing, Jiangsu Province, China
- 3 Shenzhen University, Shenzhen, Guangdong Province, China
- 4 Shenzhen University General Hospital, Shenzhen, China
Candidiasis, a prevalent class of human infections caused by fungi belonging to the Candida genus, is garnering increasing attention due to its pathogenicity and the emergence of drug resistance. The advancement of genomics technologies has offered powerful tools for investigating the pathogenic mechanisms and drug resistance characteristics of Candida. This comprehensive review provides an overview of the applications of genomics in candidiasis research, encompassing genome sequencing, comparative genomics, and functional genomics, along with the pathogenic features and core virulence factors of Candida. Moreover, this review highlights the role of genomic variations in the emergence of drug resistance, further elucidating the evolutionary and adaptive mechanisms of Candida. In conclusion, the review underscores the current state of research and prospective avenues for exploration of candidiasis, providing a theoretical basis for clinical treatments and public health strategies.
Keywords: Candidiasis, Genomics, pathogenicity, Drug Resistance, Virulence Factors
Received: 20 Nov 2024; Accepted: 12 Feb 2025.
Copyright: © 2025 Huang, Dong, Zhou, Fang, Xu, Long, Chen, Li, Qin, Mu and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qin Dong, Anqing Normal University, Anqing, China
Qi Zhou, Anqing Normal University, Anqing, China
Shitao Fang, Anqing Normal University, Anqing, China
Yiheng Xu, Anqing Normal University, Anqing, China
Hongjie Long, Anqing Normal University, Anqing, China
Jingyi Chen, Anqing Normal University, Anqing, China
Xiao Li, Anqing Normal University, Anqing, China
Huaguang Qin, Anqing Normal University, Anqing, China
Dan Mu, Anqing Normal University, Anqing, China
Xunchao Cai, Shenzhen University, Shenzhen, 518060, Guangdong Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.