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REVIEW article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1527755
This article is part of the Research Topic The Interaction Between Food Ingredients and Gut Microbiome on Health and Disease View all 7 articles

Unveiling Roles of Beneficial Gut Bacteria and Optimal Diets for Health

Provisionally accepted
Suresh Kumar Suresh Kumar 1Riya Mukherjee Riya Mukherjee 2Élcio Leal Élcio Leal 3Pratibha Gaur Pratibha Gaur 4Xiaoming Lyu Xiaoming Lyu 5Saheem Ahmad Saheem Ahmad 6Paridhi Puri Paridhi Puri 7Chung-Ming CHANG Chung-Ming CHANG 2V Samuel Raj V Samuel Raj 4Ramendra Pati Pandey Ramendra Pati Pandey 4*
  • 1 National Institute of Biologicals, Ministry of Health & Family Welfare, Govt. of India, Uttar Pradesh, India
  • 2 Chang Gung University, Taoyuan, Taichung County, Taiwan
  • 3 Federal University of Pará, Belém, Pará, Brazil
  • 4 SRM University (Delhi-NCR), Sonepat, Haryana, India
  • 5 The Third Hospital of Jinjiang, Jinjiang, China
  • 6 University of Hail, Ha'il, Hail, Saudi Arabia
  • 7 Chandigarh University, Mohali, Punjab, India

The final, formatted version of the article will be published soon.

    The gut microbiome plays a pivotal role in human health, influencing digestion, immunity, and disease prevention. Beneficial gut bacteria such as Akkermansia muciniphila, Adlercreutzia equolifasciens, and Christensenella minuta contribute to metabolic regulation and immune support through bioactive metabolites like short-chain fatty acids (SCFAs).Dietary patterns rich in prebiotics, fermented foods, and plant-based bioactive compounds, including polyphenols and flavonoids, promote microbiome diversity and stability. However, challenges such as individual variability, bioavailability, dietary adherence, and the dynamic nature of the gut microbiota remain significant. This review synthesizes current insights into gut bacteria's role in health, emphasizing the mechanisms by which dietary interventions modulate microbiota. Additionally, it highlights advancements in microbiome-targeted therapies and the transformative potential of personalized nutrition, leveraging microbiota profiling and artificial intelligence (AI) to develop tailored dietary strategies for optimizing gut health and mitigating chronic inflammatory disorders. Addressing these challenges requires a multidisciplinary approach that integrates scientific innovation, ethical frameworks, and practical implementation strategies.

    Keywords: Healthy gut bacteria, phytochemicals, Prebiotic foods & Probiotic foods, Probiotics, fatty acid

    Received: 18 Nov 2024; Accepted: 03 Feb 2025.

    Copyright: © 2025 Kumar, Mukherjee, Leal, Gaur, Lyu, Ahmad, Puri, CHANG, Raj and Pandey. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ramendra Pati Pandey, SRM University (Delhi-NCR), Sonepat, 131029, Haryana, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.