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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1526714
Increased maternal exercise of moderate intensity improves pregnancy outcomes of gestational diabetes mellitus patients through maintaining the balance of the gut microbiota
Provisionally accepted- 1Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
- 2Hangzhou Women’s Hospital, Hangzhou, China
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Background: Exercise therapy can reduce insulin resistance during pregnancy and improve glucose tolerance in women with gestational diabetes mellitus (GDM), leading to better pregnancy outcomes. This study aimed to investigate the effects of different exercise levels on GDM from the perspective of gut microbiota.Methods: Ninety patients with GDM were enrolled and divided into two groups: the L (n = 50) and the M (n = 40) groups. The L group performed 150 min of aerobic exercise per week, while the M group exercised for 200 min per week. After 8 weeks of intervention, fecal samples from each subject were collected for 16S rRNA gene sequencing.Results: Different exercise levels significantly affected membrane rupture and gestational weight gain in GDM patients (P < 0.05), but these effects were not significantly correlated by logistic regression analysis (P > 0.05). After sequencing, 4712 OTUs and 3483 OTUs were identified in the M and L groups, respectively, with 2643 OTUs overlapping between both groups. Compared to the L group, the α-diversity in the M group was significantly increased (P < 0.05). The dominant phyla were Firmicutes, Actinobacteriota, and Bacteroidota. Compared to the L group, the M group had a significantly higher abundance of Firmicutes and a significantly lower abundance of Actinobacteriota. At the genus level, LEfSe analysis revealed that moderate-intensity exercise increased the levels of Faecalibacterium, Agathobacter, Roseburia, and Osillospira, but decreased the abundance of Bifidobacterium and Coprobacillus.Conclusions: There were significant differences in the composition and structure of the gut microbiota of patients with GDM with different exercise levels.
Keywords: gestational diabetes mellitus, Gut Microbiota, Exercise, Biodiversity, Faecalibacterium
Received: 13 Nov 2024; Accepted: 14 Apr 2025.
Copyright: © 2025 Ye, Xu, Cai and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yingying Wu, Hangzhou Women’s Hospital, Hangzhou, China
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