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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1502428
SdrH enhances Staphylococcus aureus infection in diabetic wounds
Provisionally accepted- 1Department of Plastic and Burns Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China
- 2Plastic Surgery Institute of Shantou University Medical College, guangzhou, China
- 3Shantou Plastic surgery Clinical Research Center, guangzhou, China
- 4Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, zunyi, China
- 5The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University ，ZunYi,China, zunyi, China
- 6Department of Microbiology, School of Basic Medical Sciences, Army Military Medical University, China, chongqing, China
- 7Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, CN, guangzhou, China
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The sdrH gene and the icaA-C gene cluster are key factors in Staphylococcus aureus infection in diabetic wounds. Using knockout technology, we effectively deleted the sdrH and icaA-C genes, resulting in the generation of the corresponding mutant strains. It was found that infection with the sdrH single knockout strain resulted in a significant increase in wound healing rate, as well as a significant decrease in bacterial colonisation per unit area. In contrast, no significant differences were found between the icaA-C cluster knockout strain and the wild-type strain. Infection with the icaA-C/sdrH double knockout strain resulted in a significantly higher wound healing rate and a significantly lower bacterial load compared to infection caused by the wild-type strain or the sdrH single knockout strain. Our results suggest that the sdrH gene enhances the virulence of S. aureus in diabetic wounds by impairing the wound healing process by weakening the host immune response, reducing inflamma
Keywords: Kaiyu Nie: Writing -original draft, Writing -review & editing. Jinmei Peng: Software, Writing -original draft. Kaiyu Wang: Software, Writing -original draft. Weilong Shang: Supervision, Writing -review & editing. Shijie Tang: Data curation, Funding acquisition, resources, supervision
Received: 30 Sep 2024; Accepted: 08 Apr 2025.
Copyright: © 2025 Nie, Wang, Wen, Peng, Shang and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Weilong Shang, Department of Microbiology, School of Basic Medical Sciences, Army Military Medical University, China, chongqing, China
Shijie Tang, Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, CN, guangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.