Skip to main content

ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Systems Microbiology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1492710

Polygonatum kingianum polysaccharide alleviated intestinal injuries by mediating antioxidant ability and microbiota

Provisionally accepted
Reng Qiu Reng Qiu 1Chuangye Pan Chuangye Pan 1Yuxi Qin Yuxi Qin 2Qianfei Wei Qianfei Wei 3Yue Yu Yue Yu 4Ying Zhang Ying Zhang 3Xuehan Xie Xuehan Xie 1Jianqin Li Jianqin Li 3Shouhai Chen Shouhai Chen 4Kun Li Kun Li 4*Dalia Fouad Dalia Fouad 5Yi Wu Yi Wu 3Qiu Zhong Qiu Zhong 2
  • 1 Nanyang Normal University, Nanyang, Henan Province, China
  • 2 Guangxi Key Laboratory of Livestock and Poultry Breeding and Disease Prevention and Control, Nanning, Guangxi Zhuang Region, China
  • 3 Yunnan Agricultural University, Kunming, Yunnan, China
  • 4 Nanjing Agricultural University, Nanjing, China
  • 5 King Saud University, Riyadh, Riyadh, Saudi Arabia

The final, formatted version of the article will be published soon.

    Polygonatum kingianum is a representative genuine-medicinal-herb with effective bioactivities, however little knowledge is acquainted regarding the influence ofLipopolysaccharide. A total of thirty ICR mice were grouped in control (CH), induced (MH) and treated (H) groups. Mice in group H were supplemented with 100 mg/kg Polygonatum kingianum polysaccharide, while group C and M were treated with same amount of normal saline by gavage for 18 days. On the 18 th , animals in group M and H were induced by LPS (10 mg/kg). Results showed the weight of mice in group MH signally dropped (P < 0.0001), while mice in PK group had higher weight (P < 0.01).Pathological analysis found that most of the villi in mice induced by LPS were broken and short, while PK treated animals had longer and considerable integrated villi. The villi length in group CH (P < 0.0001) and H (P < 0.0001) were longer M, and the value of villi length/crypt depth in group MH were smaller than CH (P < 0.0001) and H (P < 0.0001), while the crypt depth in group MH were higher than CH (P < 0.0001) and H (P < 0.0001). Serum inspection showed that MAD (P<0.05), IL-1β (P<0.05), IL-6 (P<0.05) and TNF-α (P<0.01) were observably higher in group MH, while SOD (P<0.001), T-AOC (P<0.01) and GSH-Px (P<0.01) were notably higher in group CH and H. Microbiome sequencing of mice obtained 844477 raw and 725469 filtered reads. There were 2407 ASVs detected in animals, and there were 312 and 328 shared ASVs between CH and MH, and CH and H, respectively. There were five phyla, and twenty genera remarkable bacteria found among mice groups including genera of

    Keywords: Escherichia, Pseudomonas_E, Mailhella, Paramuribaculum, NM07-P-09, odoribacter, Nanosyncoccus, SFMI01

    Received: 07 Sep 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 Qiu, Pan, Qin, Wei, Yu, Zhang, Xie, Li, Chen, Li, Fouad, Wu and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kun Li, Nanjing Agricultural University, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.