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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microbial Physiology and Metabolism
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1485032

Bioactive Sorbicillinoid Derivatives from an Endophytic Fungus Trichoderma citrinoviride

Provisionally accepted
Yan-Ping Xia Yan-Ping Xia 1Yan Xie Yan Xie 2Li Rao Li Rao 3*Guo-Ping Yin Guo-Ping Yin 4*
  • 1 Chongqing Nan'an Renmin Hospital, Nan'an, Chongqing, China
  • 2 Department of Pharmacy, Zhengzhou Shuqing Medical College, Zhengzhou, Henan Province, China
  • 3 Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System, Medical and Pharmaceutical College, Chongqing, China
  • 4 Southwest University, Chongqing, China

The final, formatted version of the article will be published soon.

    Three new sorbicillinoid derivatives, citrinsorbicillinols A-C (1-3), along with three known compounds, trichosorbicilin G (4), dibutylphthalate (5), and 3-(4-methoxyphenyl) propanoic acid (6) were isolated from the endophyte Trichoderma citrinoviride of Coptis chinensis. Its structure was elucidated through extensive spectroscopic data analyses, computer-assisted structure elucidation (ACD/Structure Elucidator), density functional theory (DFT) calculations of the NMR spectra, and electronic circular dichroism (ECD) analyses. Biologically, compounds 1-4 exhibited potential antioxidant activity as assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays, with IC50 values ranging from 27.8 to 89.6 μM. In particular, compounds 2 and 3 demonstrated radical scavenging activity comparable to that of the positive control, ascorbic acid, with IC50 values of 27.8 and 31.2 μM, respectively. Moreover, compound 1 exhibited potential anti-inflammatory activity by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages, with an IC50 value of 52.7 μM. These findings underscore the therapeutic potential of these new sorbicillinoid derivatives for antioxidant and anti-inflammatory applications.

    Keywords: Sorbicillinoid, fungus, Trichoderma, antioxidant, anti-inflammatory

    Received: 26 Aug 2024; Accepted: 09 Jan 2025.

    Copyright: © 2025 Xia, Xie, Rao and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Li Rao, Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System, Medical and Pharmaceutical College, Chongqing, China
    Guo-Ping Yin, Southwest University, Chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.