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SYSTEMATIC REVIEW article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1483794
This article is part of the Research Topic Gut Microbiota Modulation to Mitigate Stress-Induced Functional Changes View all 7 articles

Changes of Potential Shorty-chain Fatty Acids Producing Bacteria in the gut of Patients with Spinal Cord Injury: A Systematic Review and Meta-Analysis

Provisionally accepted
Zaowei Zhong Zaowei Zhong 1Fei Fan Fei Fan 2Junqiao Lv Junqiao Lv 1Zhiqiang Wang Zhiqiang Wang 1Beiyang Wang Beiyang Wang 1Chen Deng Chen Deng 1Lin Sun Lin Sun 1*
  • 1 Shanxi Medical University, Taiyuan, China
  • 2 The Third People’s Hospital of Datong, Datong, Shanxi Province, China

The final, formatted version of the article will be published soon.

    Gut bacteria that potential produce short-chain fatty acids (SCFAs) influences the recovery of motor function in the host in patients with spinal cord injury (SCI). We aimed to conduct a review and meta-analysis of the literature on gut microbiota in SCI patients. Following the Preferred Reporting Project for Systematic Review and Meta-Analysis (PRISMA), we searched Embase, PubMed, Cochrane Library, Web of Science (WOS) and ClinicalTrials.gov. The search period was from inception to March 31, 2024. We reported standardized mean differences (d) with 95% confidence intervals (CI) and used funnel plots and Egger tests to assess publication bias. The subacute of SCI data set revealed the microflora changes in the subacute phase, and meta-analysis summarized the changes in the chronic phase. Eleven studies (720 participants) were included, 2 phyla, 1 order, and 14 genus meta-analyses performed. No substantial heterogeneity was observed, and significant publication bias was not found among the studies included. In the subacute phase of spinal cord injury, the relative abundance of Bacteroidetes, Clostridiales, Faecalbacterium, Ruminococcus, Coprococcus, Lachnospira, Dorea, Prevotella, Roseburia, Atopobium, Bifidobacterium, Bacteroides, and Blautia increased. Firmicutes and Lactobacillus decreased. In the chronic phase, Firmicutes decreased in the SCI group. Bifidobacterium, Bacteroides, Blautia, and Eubacterium were found to have a higher average proportion of abundance in patients with SCI compared to non-SCI persons, and Clostridiales, Ruminococcus, Faecalbacterium, Coprococcus, and Lachnospira showed a lower relative abundance in SCI. The genus of SCFAs-producing bacteria is lower in the chronic phase of spinal cord injury than in the subacute phase, and gut eubiosis is present in both the subacute and chronic phases.

    Keywords: spinal cord injury 1, Trauma Spinal Cord Injury2, Gut Microbiota3, meta-analysis 4, short-chain fatty acids5

    Received: 20 Aug 2024; Accepted: 22 Jan 2025.

    Copyright: © 2025 Zhong, Fan, Lv, Wang, Wang, Deng and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lin Sun, Shanxi Medical University, Taiyuan, China

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