ORIGINAL RESEARCH article

Front. Microbiol.

Sec. Microorganisms in Vertebrate Digestive Systems

Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1480077

Compound probiotics promote the growth of piglets through activating the JAK2/STAT5 signaling pathway

Provisionally accepted
zhiyuan Lizhiyuan Li1Xueyan DaiXueyan Dai1Fan YangFan Yang1Weina ZhaoWeina Zhao2zhiwei Xiongzhiwei Xiong3Wengen WanWengen Wan2Guoyun WuGuoyun Wu1tianfang Xutianfang Xu2*Huabin CaoHuabin Cao1*
  • 1Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi Province, China
  • 2Jiangxi Agricultural Technology Extension Center, Jiangxi, China
  • 3Jiangxi Biotech Vocational College, Nanchang, Jiangxi Province, China

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Compound probiotics have the characteristics of no drug resistance, residue, toxic effects, and no pollution. In order to investigate the capability of compound probiotics in piglets, a total of 16 healthy 30-day-old "Duroc × Yorkshire × Landrace" weaned piglets were randomly assigned into two groups: control group and compound probiotics (CP) group (2 mg • kg-1 basal diet compound probiotics). After 120 days, blood, liver tissues and muscle were sampled for detected the growth performance, serum biochemistry, liver hormones and related factors expression level of the JAK2/STAT5 signaling pathway. The results showed that the average daily gain was significantly increased, while the feed conversion rate (FCR) was remarkably decreased in the CP group (p<0.05). Moreover, the supplementation of compound probiotics could increase the contents of triglyceride (TG), glutamic-oxalacetic transaminase (AST), total cholesterol (TC), and glutamic-pyruvate transaminase (ALT) in serum, as well as the levels of growth hormone, insulin, thyroid-stimulating hormone and triiodothyronine.Meanwhile, the addition of compound probiotics upregulated the expression levels of GHR, JAK2, STAT3, STAT5a and STAT5b. In conclusion, compound probiotics promoted the growth performance of piglets by activating the JAK2/STAT5 signaling pathway.

Keywords: Compound Probiotics, growth performance, JAK2/STAT5 pathway, Liver, Piglet

Received: 24 Sep 2024; Accepted: 26 Feb 2025.

Copyright: © 2025 Li, Dai, Yang, Zhao, Xiong, Wan, Wu, Xu and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
tianfang Xu, Jiangxi Agricultural Technology Extension Center, Jiangxi, China
Huabin Cao, Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi Province, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material