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REVIEW article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1450442

The Role of Microbiota in Upper Gastrointestinal Malignancies

Provisionally accepted
Linli Shi Linli Shi Hongli Liu Hongli Liu *
  • Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

The final, formatted version of the article will be published soon.

    The human microbiota consists of diverse microbial communities, including bacteria, fungi, and viruses, which are distributed in various parts of the human body. This complex ecosystem plays a pivotal role in regulating various physiological processes and maintaining internal environmental homeostasis through intricate interactions with the host. Disruptions in the microbial-community balance, known as "dysbiosis", have been associated with the development of multifactorial diseases across various systems. In recent years, compelling evidence has emerged linking the microbiota to the occurrence, progression, treatment responses and prognosis of tumors. This review focuses on the research progress in the role of microbiota in upper gastrointestinal tumors and explores the potential clinical translational applications of this knowledge.

    Keywords: microbiota, Gastrointestinal malignancy, microenvironment, Microbial dysbiosis, biomarker

    Received: 18 Jun 2024; Accepted: 06 Jan 2025.

    Copyright: © 2025 Shi and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hongli Liu, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.