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REVIEW article

Front. Microbiol.
Sec. Microbial Symbioses
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1442282
This article is part of the Research Topic Harnessing Natural Plant Extracts and Probiotics to Enhance Host-Gut Microbiome Interactions View all 12 articles

AhR governs lipid metabolism：the role of gut microbiota

Provisionally accepted
婉如 郑 婉如 郑 1梦宽 刘 梦宽 刘 1杰 马 杰 马 1*欣宇 吕 欣宇 吕 1翠梅 何 翠梅 何 1Jie YIN Jie YIN 2
  • 1 College of Animal Science and Technology, Guangxi University, Nanning, Guangxi Zhuang Region, China
  • 2 College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan Province, China

The final, formatted version of the article will be published soon.

    The Aryl Hydrocarbon Receptor (AhR) is widely present in mammalian bodies, showing high affinity for various exogenous substances such as polycyclic aromatic hydrocarbons (PAHs) and coumarin. Under physiological conditions, AhR mainly participates in regulating the body's immune response, cell proliferation, and apoptosis among a series of processes. Recent studies have revealed a close connection between AhR and lipid metabolism. The gut microbiota plays a significant role in regulating host lipid metabolism. Growing evidence suggests an inseparable link between gut microbiota and AhR signaling. This review summarizes the relationship between AhR and lipid metabolism disorders, as well as the interaction between gut microbiota and AhR, exploring how this interaction modulates host lipid metabolism.

    Keywords: Aryl hydrocarbon receptor, Gut Microbiota, Lipid Metabolism, Inflammation, metabolic disease

    Received: 01 Jun 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 郑, 刘, 马, 吕, 何 and YIN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: 杰 马, College of Animal Science and Technology, Guangxi University, Nanning, 530004, Guangxi Zhuang Region, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.