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REVIEW article

Front. Microbiol.
Sec. Microbiotechnology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1520446
This article is part of the Research Topic Exploration of Marine Microorganisms for Sustainable Biotechnology View all articles

Genome Mining and Biosynthetic Pathways of Marine-Derived Fungal Bioactive Natural Products

Provisionally accepted
Caihua Han Caihua Han 1*Anjing Song Anjing Song 1*Yueying He Yueying He 1*Liu Yang Liu Yang 1*Litong Chen Litong Chen 2*Wei Dai Wei Dai 3*Qilin Wu Qilin Wu 1*Si-Wen Yuan Si-Wen Yuan 1*
  • 1 Department of Bioengineering, Zunyi Medical University, Zhuhai, Guangdong Province, China
  • 2 School of Atmospheric Sciences, Sun Yat-sen University, Zhuhai Campus, Zhuhai, Guangdong Province, China
  • 3 Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Marine fungal natural products (MFNPs) are a vital source of pharmaceuticals, primarily synthesized by relevant biosynthetic gene clusters (BGCs). However, many of these BGCs remain silent under standard laboratory culture conditions, delaying the development of novel drugs from MFNPs to some extent. This review highlights recent efforts in genome mining and biosynthetic pathways of bioactive natural products from marine fungi, focusing on methods such as bioinformatics analysis, gene knockout, and heterologous expression to identify relevant BGCs and elucidate the biosynthetic pathways and enzyme functions of MFNPs. The research efforts presented in this review provide essential insights for future gene-guided mining and biosynthetic pathway analysis in MFNPs.Marine microorganisms, thriving in unique oceanic environments, possess specialized metabolic and defensive mechanisms, thereby facilitating the production of structurally novel bioactive MNPs, making marine microorganisms as crucial sources for new MNPs. Approximately 11362 new MNPs have been discovered from marine microorganisms, constituting 30% of all known marine natural products.

    Keywords: marine fungi, Marine Natural Products, Biosynthetic gene clusters, genome mining, biosynthesis

    Received: 31 Oct 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Han, Song, He, Yang, Chen, Dai, Wu and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Caihua Han, Department of Bioengineering, Zunyi Medical University, Zhuhai, Guangdong Province, China
    Anjing Song, Department of Bioengineering, Zunyi Medical University, Zhuhai, Guangdong Province, China
    Yueying He, Department of Bioengineering, Zunyi Medical University, Zhuhai, Guangdong Province, China
    Liu Yang, Department of Bioengineering, Zunyi Medical University, Zhuhai, Guangdong Province, China
    Litong Chen, School of Atmospheric Sciences, Sun Yat-sen University, Zhuhai Campus, Zhuhai, 519082, Guangdong Province, China
    Wei Dai, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong Province, China
    Qilin Wu, Department of Bioengineering, Zunyi Medical University, Zhuhai, Guangdong Province, China
    Si-Wen Yuan, Department of Bioengineering, Zunyi Medical University, Zhuhai, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.