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REVIEW article

Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1519906

An Integrative Review on the Risk Factors, Prevention, and Control Strategies for Carbapenem-Resistant Acinetobacter baumannii Colonization in Critically Ill Patients

Provisionally accepted
Shihan Zhang Shihan Zhang 1,2Jie Xiao Jie Xiao 1,2Yanan Li Yanan Li 1,2Wei Li Wei Li 3Yihui Li Yihui Li 1,2Mingmin Pang Mingmin Pang 1,2Meichen Yan Meichen Yan 1,2Hui Han Hui Han 1,2Yi Cui Yi Cui 1,2Xuehai Zhang Xuehai Zhang 1,2Hao Wang Hao Wang 1,2*
  • 1 Department of critical care medicine, Qilu Hospital of Shandong University, Jinan, Shandong Province, China
  • 2 Innovation Research Center for Sepsis and Multiple Organ Injury, Shandong University, Jinan, China
  • 3 Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    The presence of Carbapenem-Resistant Acinetobacter baumannii (CRAb) has become one of the leading causes of life-threatening, hospital-acquired infections globally, especially with a notable prevalence in Intensive Care Units (ICUs).The cross-transmission of microorganisms between patients and the hospital setting is crucial in the development of CRAb colonization and subsequent infections. Recent studies indicate that colonization typically precedes infection, suggesting the effectiveness and necessity of preventing CRAb colonization as a primary method to lower infection risks. As CRAb infections tend to draw more attention due to their severe symptoms and poor outcomes, understanding the link between colonization and infection is equally vital. To establish a foundation for prevention and control strategies against CRAb colonization in ICUs, we present a comprehensive review of research pertaining to CRAb in ICUs. This encompasses an analysis of the resistance mechanisms and epidemiological characteristics of CRAb, a discussion on associated risk factors, adverse outcomes, and an evaluation of detection methods and preventive strategies.

    Keywords: crab, colonization, Risk factors, hazard, prevention

    Received: 30 Oct 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Zhang, Xiao, Li, Li, Li, Pang, Yan, Han, Cui, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hao Wang, Department of critical care medicine, Qilu Hospital of Shandong University, Jinan, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.