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REVIEW article

Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1518045

Unveiling the Role of BON domain-containing proteins (BDCPs) in Antibiotic Resistance

Provisionally accepted
Shengwei Sun Shengwei Sun 1*Jinju Chen Jinju Chen 2*
  • 1 School of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden
  • 2 Loughborough University, Loughborough, United Kingdom

The final, formatted version of the article will be published soon.

    The alarming rise of antibiotic-resistant Gram-negative bacteria poses a global health crisis. Their unique outer membrane restricts antibiotic access. While diffusion porins are well-studied, the role of BON domain-containing proteins (BDCPs) in resistance remains unexplored. We analyze protein databases, revealing widespread BDCP distribution across environmental bacteria. We further describe their conserved core domain structure, a key for understanding antibiotic transport. Elucidating the genetic and biochemical basis of BDCPs offers a novel target to combat antibiotic resistance and restore bacterial susceptibility to antibiotics.

    Keywords: Cell envelope, BON domain-containing protein, antibiotic resistance, structure and function, pathogens

    Received: 27 Oct 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Sun and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shengwei Sun, School of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden
    Jinju Chen, Loughborough University, Loughborough, United Kingdom

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.