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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Virology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1517725

Evaluation of autophagic and apoptotic markers during infection with animal virus causing hemorrhagic fever in rabbits

Provisionally accepted
Dominika Bębnowska Dominika Bębnowska 1,2*Sylwia Rzeszotek Sylwia Rzeszotek 3Agnieszka Kolasa Agnieszka Kolasa 3Karolina Wiśniewska Karolina Wiśniewska 2,4Magdalena Żabińska Magdalena Żabińska 4Aneta Szulc Aneta Szulc 4Zuzanna Cyske Zuzanna Cyske 2,4Karolina Pierzynowska Karolina Pierzynowska 2,4Aleksandra Wilk Aleksandra Wilk 3Paulina Niedźwiedzka-Rystwej Paulina Niedźwiedzka-Rystwej 1,2,4
  • 1 University of Szczecin, Szczecin, Poland
  • 2 Center for Experimental Immunology and Immunobiology in Infectious Disease and Cancer, University of Szczecin, Szczecin, Poland
  • 3 Pomeranian Medical University, Szczecin, West Pomeranian, Poland
  • 4 Department of Molecular Genetics of Bacteria, Faculty of Biology, University of Gdansk, Gdansk, Poland

The final, formatted version of the article will be published soon.

    Lagovirus europaeus/GI.1 and GI.2 cause severe Rabbit Haemorrhagic Disease, and immune processes are among the important pathomechanisms of the disease. Autophagy and apoptosis are two key mechanisms involved in the host antiviral response. Both of these processes have been characterized in infection with GI.1 strains, while data on infection with GI.2 strains still need to be studied. This is particularly important because infection with different strains is associated with a different host immune response profile. In this work, we analyzed the expression of selected genes and proteins (involved in autophagic flux in the liver, spleen, kidney and peripheral blood, but also apoptotic cell death in the liver and peripheral blood of rabbits infected with the GI.2 strain. As a result, we showed that autophagy is strongly activated in the liver, spleen and kidney of infected rabbits, and confirmed the activation of apoptosis in the liver.

    Keywords: Lagovirus europaeus, Rabbit haemorrhagic disease, Autophagy, Apoptosis, Rabbits

    Received: 08 Nov 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Bębnowska, Rzeszotek, Kolasa, Wiśniewska, Żabińska, Szulc, Cyske, Pierzynowska, Wilk and Niedźwiedzka-Rystwej. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dominika Bębnowska, University of Szczecin, Szczecin, Poland

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.