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REVIEW article

Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1503130

Advances in Research on the Impact and Mechanisms of Pathogenic Microorganism Infections on Pyroptosis

Provisionally accepted
攀 尚 攀 尚 1,2Mailin Gan Mailin Gan 1,2Ziang Wei Ziang Wei 1,2Hu Sj Hu Sj 1,2Lei Song Lei Song 1,2Jinkang Feng Jinkang Feng 1,2Lei Chen Lei Chen 1,2Lili Niu Lili Niu 1,2Yan Wang Yan Wang 1,2Shunhua Zhang Shunhua Zhang 1,2Linyuan Shen Linyuan Shen 1,2Li Zhu Li Zhu 1,2*Ye Zhao Ye Zhao 1,2*
  • 1 Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan Province, China
  • 2 State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death characterized by the activation of gasdermin proteins, leading to the formation of pores in the cell membrane, continuous cell swelling, and eventual membrane rupture. This process results in the release of intracellular contents, including pro-inflammatory cytokines like IL-1β and IL-18, which subsequently trigger a robust inflammatory response. This process is a crucial component of the body's innate immune response and plays a significant role in combating infections. There are four main pathways through which pathogenic microorganisms induce pyroptosis: the canonical inflammasome pathway, the non-canonical inflammasome pathway, the apoptosis-associated caspase-mediated pathway, and the granzyme-mediated pathway. This article provides a brief overview of the effects and mechanisms of pathogen infections on pyroptosis.

    Keywords: Pathogenic microorganisms, pyroptosis, Inflammasome, caspase, granzyme

    Received: 28 Sep 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 尚, Gan, Wei, Sj, Song, Feng, Chen, Niu, Wang, Zhang, Shen, Zhu and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Li Zhu, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, Sichuan Province, China
    Ye Zhao, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.