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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microbial Symbioses
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1501999
This article is part of the Research Topic Bifidobacteria: Exploring the Roles of These Microbiome Guardians and Their Effects on Human Health View all 5 articles

Bifidobacterium longum JBLC-141 Alleviates Hypobaric Hypoxia-Induced Intestinal Barrier Damage by Attenuating Inflammatory Responses and Oxidative Stress

Provisionally accepted
Xiang-Yang Li Xiang-Yang Li 1*Jin Shang Jin Shang 1*Xiao-Juan Wang Xiao-Juan Wang 1*Long-Fei Ren Long-Fei Ren 2*Lei Zhang Lei Zhang 2*
  • 1 The First Clinical Medical College, Lanzhou University, Lanzhou, China, Lanzhou, Gansu Province, China
  • 2 First Hospital of Lanzhou University, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    Hypobaric hypoxia exposure occurs at high altitudes, including plateaus, and affects normal intestinal function and microbiota composition. Exposure induces an intestinal inflammatory response and oxidative stress injury, ultimately disrupting intestinal homeostasis and causing barrier damage. Thus, due to its anti-inflammatory, antioxidative, and intestinal microbiota-regulating properties, Bifidobacterium longum is a potentially effective probiotic intervention to protect the intestinal barrier during low-pressure hypoxia on plateaus. However, its mechanism of action is not fully defined. In this study, we investigate the mechanism by which B.

    Keywords: Bifidobacterium longum, hypobaric hypoxia, oxidative stress, intestinal barrier, intestinal flora 1 DAO, diamine oxidase, DLA, d-lactic acid, H&E, hematoxylin and eosin, ILA, indole-3-lactic acid, LB, hypoxia plus probiotic group, LDA, Linear discriminant analysis, LEfSe, linear discriminant analysis effect size, LS, hypoxia plus saline group

    Received: 26 Sep 2024; Accepted: 20 Nov 2024.

    Copyright: © 2024 Li, Shang, Wang, Ren and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiang-Yang Li, The First Clinical Medical College, Lanzhou University, Lanzhou, China, Lanzhou, Gansu Province, China
    Jin Shang, The First Clinical Medical College, Lanzhou University, Lanzhou, China, Lanzhou, Gansu Province, China
    Xiao-Juan Wang, The First Clinical Medical College, Lanzhou University, Lanzhou, China, Lanzhou, Gansu Province, China
    Long-Fei Ren, First Hospital of Lanzhou University, Lanzhou, Gansu Province, China
    Lei Zhang, First Hospital of Lanzhou University, Lanzhou, Gansu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.