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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1501951
This article is part of the Research Topic Harnessing Marine Biodiversity for Novel Antimicrobial Agents Against Multidrug-Resistant Pathogens View all 6 articles

Marine actinobacteria metabolites: unlocking new treatments for acne vulgaris

Provisionally accepted
María Clara De La Hoz Romo María Clara De La Hoz Romo 1Luis Eduardo Diaz Barrera Luis Eduardo Diaz Barrera 1*Javier Goméz-León Javier Goméz-León 2Marynes Quintero Marynes Quintero 2Luisa Villamil Luisa Villamil 1*
  • 1 Universidad de La Sabana, Chía, Colombia
  • 2 José Benito Vives of Andréis Marine and Coastal Research Institute, Santa Marta, Magdalena, Colombia

The final, formatted version of the article will be published soon.

    Marine-derived actinobacteria isolated from sponge Cliona varians and soft coral Eunicea fusca were screened for antibacterial activity against acne-related bacteria, specifically Staphylococcus epidermidis ATCC 14990, methicillin-resistant Staphylococcus aureus ATCC BAA44, and Cutibacterium acnes ATCC 6919. Cytotoxicity assays were performed on human dermal fibroblast (HDFa) and keratinocyte (HaCaT) cell lines to assess the safety profile of the extracts. Chemical characterization was conducted using high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). Among the extracts, six derived from Kocuria sp., Rhodococcus sp., Nocardia sp., Micrococcus sp., and Streptomyces sp. demonstrated significant antibacterial activity. Notably, extract Z9.216 from Kocuria sp. exhibited the highest efficacy, inhibiting S. epidermidis by 68%, S. aureus by 93%, and C. acnes by 98.7% at a concentration of 0.003 mg/mL, which was comparable to the standard antibiotics erythromycin and vancomycin, while maintaining over 90% cell viability in both HDFa and HaCaT cell lines. Untargeted metabolomic analysis suggested that antibacterial activity might be associated with compounds from the chemical families of alkaloids, terpenoids, and fatty acids, among others. These findings highlight the therapeutic potential of marine actinobacteria in underexplored environments as a promising strategy for treating acne vulgaris, a chronic inflammatory skin condition.

    Keywords: Marine actinobacteria, Acne Vulgaris, Antibacterial activity, secondary metabolites, Cutibacterium acnes

    Received: 25 Sep 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Clara De La Hoz Romo, Diaz Barrera, Goméz-León, Quintero and Villamil. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Luis Eduardo Diaz Barrera, Universidad de La Sabana, Chía, Colombia
    Luisa Villamil, Universidad de La Sabana, Chía, Colombia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.