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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 15 - 2024 |
doi: 10.3389/fmicb.2024.1500146
This article is part of the Research Topic Research Advances and Challenges in Emerging and Re-Emerging Viral Diseases View all 9 articles
Severe fever with thrombocytopenia syndrome virus was found in Northern Jiangxi Province, China
Provisionally accepted
Haijun Hu
1*
Ying He
2*
Fei Chen
1*
Zhanbin Liu
3*
Wei Wang
1*
Shu Yang
1*
Ke Qian
1*
Zhuan Zhan
2*
Yangping Guo
4*
Hui Li
1*
Weiqing Zheng
1,5*- 1 The Collaboration Unit for State Key Laboratory of Infectious Disease Prevention and Control, Jiangxi Provincial Health Commission Key Laboratory of Pathogenic Diagnosis and Genomics of Emerging Infectious Diseases, Nanchang Centre for Diseases Control and Prevention, Nanchang, China
- 2 The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
- 3 Nanchang Police Dog Base of the Ministry of Public Security, Nanchang, Jiangxi Province, China
- 4 Donghu District Center for Disease Control and Prevention, Nanchang, Jiangxi Province, China
- 5 NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, Hainan Province, China
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease discovered in China in 2009. SFTS monitoring has been carried out since 2010 in mainland China. In recent years, human infection with SFTS virus (SFTSV) has frequently been detected in Jiujiang of Jiangxi Province, Central China. Here, four patients were positive for SFTSV infection. However, the subjects like humans, animals and ticks around the cases were all detected as negative for the virus infection. The full-length L, M, and S segment sequences of the strains were consistently clustered into two genotypes, namely the genotype C5 and the genotype C4. The strains belonging to genotype C5 were detected for recombination signal with moderate confidence by all the six methods, with a significance level of p value <0.05 and the RDP recombination consensus score (RDPRCS) of 0.41.The recombination event might have occurred between the minor parent (2011YPQ11, C3/C3/C3) and major parent (SPL053A, J1/ J1/ J1). However, there was no genetic recombination detected in the genotype C4. This is the first time genotype C5 and genotype C4of SFTSVs identified in Jiujiang City, Jiangxi Province of Central China. The genotype C5 underwent genetic recombination in this region.
Keywords: Severe fever with thrombocytopenia syndrome, Genotype, C4 and C5, Genetic recombination, Jiangxi
Received: 22 Sep 2024; Accepted: 21 Nov 2024.
Copyright: © 2024 Hu, He, Chen, Liu, Wang, Yang, Qian, Zhan, Guo, Li and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Haijun Hu, The Collaboration Unit for State Key Laboratory of Infectious Disease Prevention and Control, Jiangxi Provincial Health Commission Key Laboratory of Pathogenic Diagnosis and Genomics of Emerging Infectious Diseases, Nanchang Centre for Diseases Control and Prevention, Nanchang, China
Ying He, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China
Fei Chen, The Collaboration Unit for State Key Laboratory of Infectious Disease Prevention and Control, Jiangxi Provincial Health Commission Key Laboratory of Pathogenic Diagnosis and Genomics of Emerging Infectious Diseases, Nanchang Centre for Diseases Control and Prevention, Nanchang, China
Zhanbin Liu, Nanchang Police Dog Base of the Ministry of Public Security, Nanchang, Jiangxi Province, China
Wei Wang, The Collaboration Unit for State Key Laboratory of Infectious Disease Prevention and Control, Jiangxi Provincial Health Commission Key Laboratory of Pathogenic Diagnosis and Genomics of Emerging Infectious Diseases, Nanchang Centre for Diseases Control and Prevention, Nanchang, China
Shu Yang, The Collaboration Unit for State Key Laboratory of Infectious Disease Prevention and Control, Jiangxi Provincial Health Commission Key Laboratory of Pathogenic Diagnosis and Genomics of Emerging Infectious Diseases, Nanchang Centre for Diseases Control and Prevention, Nanchang, China
Ke Qian, The Collaboration Unit for State Key Laboratory of Infectious Disease Prevention and Control, Jiangxi Provincial Health Commission Key Laboratory of Pathogenic Diagnosis and Genomics of Emerging Infectious Diseases, Nanchang Centre for Diseases Control and Prevention, Nanchang, China
Zhuan Zhan, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China
Yangping Guo, Donghu District Center for Disease Control and Prevention, Nanchang, Jiangxi Province, China
Hui Li, The Collaboration Unit for State Key Laboratory of Infectious Disease Prevention and Control, Jiangxi Provincial Health Commission Key Laboratory of Pathogenic Diagnosis and Genomics of Emerging Infectious Diseases, Nanchang Centre for Diseases Control and Prevention, Nanchang, China
Weiqing Zheng, The Collaboration Unit for State Key Laboratory of Infectious Disease Prevention and Control, Jiangxi Provincial Health Commission Key Laboratory of Pathogenic Diagnosis and Genomics of Emerging Infectious Diseases, Nanchang Centre for Diseases Control and Prevention, Nanchang, China
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