Skip to main content

ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Systems Microbiology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1495709
This article is part of the Research Topic Artificial Intelligence in Pathogenic Microorganism Research View all 7 articles

A Transformer-based deep learning model for identifying the occurrence of acute hematogenous osteomyelitis and predicting blood culture results

Provisionally accepted
Yingtu Xia Yingtu Xia 1Jiuhui Su Jiuhui Su 2*Qiang Kang Qiang Kang 3Yi Gao Yi Gao 4
  • 1 Detment of Orthopedics, The Second Hospital of Dalian Medical University, Dalian, China
  • 2 Haicheng Orthopedic Hospital, Haicheng, China
  • 3 Xing'an League People's Hospital of Inner Mongolia, Ulan Hot, China
  • 4 Sheng Jing Hospital Affiliated, China Medical University, Shenyang, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Background: Acute hematogenous osteomyelitis is the most common form of osteomyelitis in children. In recent years, the incidence of osteomyelitis has been steadily increasing. For pediatric patients, clearly describing their symptoms can be quite challenging, which often necessitates the use of complex diagnostic methods, such as radiology. For those who have been diagnosed, the ability to culture the pathogenic bacteria significantly affects their treatment plan.Method: A total of 634 patients under the age of 18 were included, and the correlation between laboratory indicators and osteomyelitis, as well as several diagnoses often confused with osteomyelitis, was analyzed. Based on this, a Transformer-based deep learning model was developed to identify osteomyelitis patients. Subsequently, the correlation between laboratory indicators and the length of hospital stay for osteomyelitis patients was examined. Finally, the correlation between the successful cultivation of pathogenic bacteria and laboratory indicators in osteomyelitis patients was analyzed, and a deep learning model was established for prediction.Result: The laboratory indicators of patients are correlated with the presence of acute hematogenous osteomyelitis, and the deep learning model developed based on this correlation can effectively identify patients with acute hematogenous osteomyelitis. The laboratory indicators of patients with acute hematogenous osteomyelitis can partially reflect their length of hospital stay. Although most laboratory indicators lack a direct correlation with the ability to culture pathogenic bacteria in patients with acute hematogenous osteomyelitis, our model can still predict whether the bacteria can be successfully cultured. Artificial intelligence identifies osteomyelitis Conclusion: Laboratory indicators, as easily accessible medical information, can identify osteomyelitis in pediatric patients. They can also predict whether pathogenic bacteria can be successfully cultured, regardless of whether the patient has received antibiotics beforehand. This not only simplifies the diagnostic process for pediatricians but also provides a basis for deciding whether to use empirical antibiotic therapy or discontinue treatment for blood cultures.

    Keywords: Deep learning1, Osteomyelitis2, Blood culture3, Anti-infection treatment4, Pathogenic microorganism5

    Received: 13 Sep 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Xia, Su, Kang and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiuhui Su, Haicheng Orthopedic Hospital, Haicheng, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.