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REVIEW article

Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1495011

Exploring the Therapeutic Potential of Different Sources of Mesenchymal stem cells: Novel Approach to Combat Burn Wound Infections

Provisionally accepted
Shahrzad Aliniay-Sharafshadehi Shahrzad Aliniay-Sharafshadehi 1Mohammad Hasan Yousefi Mohammad Hasan Yousefi 2,3Mojtaba Kashfi Mojtaba Kashfi 4,5Hamed Afkhami Hamed Afkhami 3,5,6*Seyed Mehdi Ghoreyshiamiri Seyed Mehdi Ghoreyshiamiri 7
  • 1 Department of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Alborz, Iran
  • 2 Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Qom University of Medical Sciences, Qom, Qom, Iran
  • 3 Cellular and Molecular Research Centre, Qom University of Medical Sciences, Qom, Iran, Qom, Qom, Iran
  • 4 Fellowship in Clinical Laboratory Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
  • 5 Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Semnan, Iran
  • 6 Department of Medical Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran, Tehran, Alborz, Iran
  • 7 Tehran University of Medical Sciences, Tehran, Tehran, Iran

The final, formatted version of the article will be published soon.

    The most prevalent and harmful injuries are burns, which are still a major global health problem. Burn injuries can cause issues because they boost the inflammatory and metabolic response, which can cause organ malfunction and systemic failure. On the other hand, a burn wound infection creates an environment that is conducive to the growth of bacteria and might put the patient at risk for sepsis. Also, scarring is unavoidable, and this results in patients having functional and cosmetic issues. Wound healing is an amazing phenomenon with a complex mechanism that deals with different types of cells and biomolecules. Cell therapy using stem cells is one of the most challenging treatment methods that accelerates the healing of burn wounds. Since 2000, the use of mesenchymal stem cells (MSCs) in regenerative medicine and wound healing has increased. They can be extracted from various tissues, such as bone marrow, fat, the umbilical cord, and the amniotic membrane. According to studies, stem cell therapy for burn wounds increases angiogenesis, has anti-inflammatory properties, slows the progression of fibrosis, and has an excellent ability to differentiate and regenerate damaged tissue. Figuring out the main preclinical and clinical problems that stop people from using MSCs and then suggesting the right ways to improve therapy could help show the benefits of MSCs and move stem cell-based therapy forward. This review's objective is to assess mesenchymal stem cell therapy's contribution to the promotion of burn wound healing.

    Keywords: Mesenchymal stem cell (MSCs), burn injury, Infection, stem cells-based therapy, Wound Healing

    Received: 11 Sep 2024; Accepted: 08 Nov 2024.

    Copyright: © 2024 Aliniay-Sharafshadehi, Yousefi, Kashfi, Afkhami and Ghoreyshiamiri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hamed Afkhami, Cellular and Molecular Research Centre, Qom University of Medical Sciences, Qom, Iran, Qom, Qom, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.