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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1494049

The Impact of Different Gastrointestinal Reconstruction Techniques on Gut Microbiota After Gastric Cancer Surgery

Provisionally accepted
Yu Yang Yu Yang 1,2Guo-Min Zhou Guo-Min Zhou 1,2*Jin Chen Jin Chen 2*Rui Ming Rui Ming 2*Dong Zhang Dong Zhang 2*Huai-Wu Jiang Huai-Wu Jiang 1,2*Hang-Yu Zhou Hang-Yu Zhou 2*
  • 1 Southwest Medical University, Luzhou, China
  • 2 Sichuan Mianyang 404 Hospital, Mianyang, China

The final, formatted version of the article will be published soon.

    Gastric cancer is one of the common malignant tumors in the digestive tract, with high incidence and mortality rates. In the clinical treatment of gastric cancer, radical surgery is considered the most effective treatment intervention, and gastrointestinal reconstruction is an essential procedure in clinical treatment. This study aims to explore the impact of Double tract reconstruction (DTR) and Roux-en-Y gastrointestinal reconstruction (R-Y) on the gut microbiota of gastric cancer patients and their potential role in postoperative recovery and long-term health. Through random sampling, patients who underwent gastric cancer surgery at Sichuan Mianyang 404 Hospital were included in the study and randomly divided into the DTR group and the R-Y group. Both groups of patients received the same perioperative management. The study collected fecal and blood samples before and after surgery for 16S rRNA sequencing analysis and blood-related index analysis. The results showed that there was no significant difference in gut microbiota diversity between the two groups. Compared with the R-Y group, the analysis found that the DTR surgical method could significantly change the structure of the gut microbiota, affecting the types, quantities, and ratios of gut bacteria. For instance, after surgery, there was an enrichment of conditional pathogens related to postoperative infection, such as Pseudomonas aeruginosa, Enterococcus gallinarum, Porphyromonas somerae, and Citrobacter freundii. In addition, compared with the R-Y group, the postoperative DTR group had poor nutritional absorption ability, that is, the F/B ratio was low. The R-Y group showed a richer Bacteroidia and lower Proteobacteria abundance after surgery, as well as a higher F/B ratio. These findings provide new insights into the changes in the gut microbiota after gastric cancer surgery and may have important implications for postoperative recovery and long-term health management.

    Keywords: gastric cancer, Gut Microbiota, 16S rRNA sequencing, Double tract reconstruction, Roux-en-Y gastrointestinal reconstruction

    Received: 10 Sep 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Yang, Zhou, Chen, Ming, Zhang, Jiang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Guo-Min Zhou, Southwest Medical University, Luzhou, China
    Jin Chen, Sichuan Mianyang 404 Hospital, Mianyang, China
    Rui Ming, Sichuan Mianyang 404 Hospital, Mianyang, China
    Dong Zhang, Sichuan Mianyang 404 Hospital, Mianyang, China
    Huai-Wu Jiang, Southwest Medical University, Luzhou, China
    Hang-Yu Zhou, Sichuan Mianyang 404 Hospital, Mianyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.